![]() While supporting massive, reversible importin-mediated cargo influx, FG/FxFG, GLFG or mixed hydrogels remained firm barriers towards inert objects that lacked nuclear transport signals. We now show that GLFG repeats, the other major FG repeat type, can also form highly selective hydrogels. ![]() We had shown earlier that the permeability barrier can be reconstituted in the form of a saturated FG/FxFG repeat hydrogel. Objects larger than ≈30 kDa can efficiently cross this barrier only when bound to nuclear transport receptors (NTRs) that confer translocation-promoting properties. It is freely permeable for small molecules. The permeability barrier of nuclear pore complexes (NPCs) controls all nucleo-cytoplasmic exchange.
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